In Vivo Transfection | RNA/DNA Delivery

Pulmonary toxicity studies are preclinical studies that are conducted to evaluate the potential adverse effects of a substance on the respiratory system, including the lungs and airways. These studies are typically conducted in laboratory animals, such as rats, mice, or dogs, to assess the safety of a drug or other substance before testing in humans.…

Best practices for GLP compliance in pharmacology and toxicology studies involve adhering to the fundamental principles of Good Laboratory Practice. These practices help ensure the generation of high-quality, reliable, and reproducible data that can be used for regulatory submissions and decision-making. Below are some best practices for GLP compliance in pharmacology and toxicology studies: By…

What are Pharmacokinetics and pharmacodynamics? Pharmacokinetics and pharmacodynamics are two terms that are often used interchangeably in the medical field. Pharmacokinetics is the study of how a drug is absorbed, distributed, metabolized, and excreted by the body. Pharmacodynamics is the study of how a drug affects the body. The influence of pharmacokinetics and pharmacodynamics on…

Hematological toxicity studies are preclinical studies that are conducted to evaluate the potential adverse effects of a substance on the blood and hematopoietic system. These studies are typically conducted in laboratory animals, such as mice, rats, or dogs, to assess the safety of a drug or other substance before testing in humans. The primary objective…

Personalized medicine, also known as precision medicine, is an emerging approach to healthcare that tailors prevention, diagnosis, and treatment strategies to an individual patient’s unique genetic, environmental, and lifestyle factors. Genomics, the study of an organism’s complete set of DNA, plays a crucial role in enabling personalized medicine by providing insights into a person’s genetic…

Biopharmaceuticals are a class of therapeutic drugs derived from biological sources, such as living organisms or their components. They include proteins, nucleic acids, and complex carbohydrates, as well as living cells and tissues. Biopharmaceuticals are distinct from traditional small-molecule drugs, which are chemically synthesized. Due to their complex nature and biological origin, biopharmaceuticals often have…

Gene therapy is a promising and rapidly evolving field of medical research that aims to treat or prevent diseases by introducing, modifying, or repairing genetic material within a patient’s cells. It offers a potential solution for various genetic disorders, certain types of cancer, and some viral infections. Gene therapy can be broadly categorized into two…

Microbiome research is a rapidly expanding field that focuses on understanding the complex communities of microorganisms, including bacteria, fungi, viruses, and protozoa, that inhabit various environments within and on the human body. These microbial communities, collectively referred to as the human microbiome, play a crucial role in human health and disease. The majority of microbiome…

Neurotoxicity studies are preclinical studies that are conducted to evaluate the potential adverse effects of a substance on the nervous system. These studies are typically conducted in laboratory animals, such as rats or mice, to assess the safety of a drug or other substance before testing in humans. The primary objective of neurotoxicity studies is…

Dose-ranging studies are an important component of preclinical testing for new drugs, chemicals, and other substances. These studies aim to determine the appropriate dosage range for the substance, and to identify any potential adverse effects of the substance at different doses. The primary objective of dose-ranging studies is to determine the optimal dose range for…